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Contraindicated (1)pentobarbital will lessen the extent or influence of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or result of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Solid CYP3A4 inducers may well lower midostaurin c